Vyom Bhargava

HMC Hospital and Advanced Neuro-Spine Institute , India

Presentation Title:

Lessons from a glioblastoma patient surviving 20 years progression free

Abstract

Glioblastoma (GBM) is the commonest primary brain tumor and also the deadliest of all known human cancers, with median survival about 14 months after diagnosis. All advancements (functional & Intraoperative MRI and 5-ALA guided surgical excision, monoclonal chemotherapy, Temozolomide combined radiotherapy, Intensity-modulated & Stereotactic radiosurgery etc.) have added only few months in survival of GBM patients in last 3 decades. Shorter lifespan justifying subtotal resection for functional preservation, a common, but not optimum scenario for patients.

A 22 years old man, on Valproate for an year for secondary epilepsy due to suspected granuloma- diagnosed on Plain-CT done in April 2004, came in emergency with raised intracranial pressure and focal deficits in July, 2005. Contrast-CT showed a heterogeneously enhancing large parenchymal mass in left parieto-Occipital region. After Microsurgical Gross total removal (GTR) he became asymptomatic. He received irradiation but no chemotherapy. He has remained asymptomatic living normal independent life, except hypothyroidism and hypogonadism corrected with medications at his latest follow up on July 2025, without recurrence on latest CEMR in December 2023. Twenty years without recurrence is the longest survival reported in India (less than 10 reported worldwide). His 4 relatives had cancer (not of brain) including both of parents. Wax blocks were not available for immunohistochemistry (IHC) to review IHC.

This case provides the possibility of giving HOPE of living long to next suspected glioblastoma during consent or counselling and a reason to achieve GTR in most cases to find some of such lucky cases. Specimen should be preserved for newer test of future. Building meaningful relation with patient is needed for long follow ups.

Key Message: Cure is possible for glioblastoma with Care (to preserve functions) and dare (for GTR), therefore share “the possibility of long life” and spare “records and biopsy for years” for all of them.

Biography

Vyom Bhargava has completed his MCh in Neurosurgery at the age of 29 years from Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow, India. He is the head of Neurosurgery department of HMC Hospitals and Advanced Neuro-Spine Institute (Ludhiana & Moga), India. He has been instrumental in stating neurosurgery in a small township in state of Punjab where it was the first and the only Neurosurgical center for over 15 years. He has been lucky to have very safe and good outcomes in majority of his patients through out his carrier. Be it surgeries during pregnancy, permanent endocrinopathy in pituitary tumor, brain hematoma or aneurysm, intramedullary tumor of spine or many others, outcomes have been good to excellent, barely using ventilatory support in postoperative period, and low perioperative mortality - morbidity. He has publications has been related so far to craniovertebral junction anomalies and brain & pituitary tumors. Long term follow up has been the strength of his publications.

4th International Conference on Neuroscience and Mental Health

Vyom Bhargava

Presentation Title:

Lessons from a glioblastoma patient surviving 20 years progression free

Abstract

Biography

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