Lilach Soreq
UCL, UKPresentation Title:
miRNA expression changes in PD blood leukocytes
Abstract
Parkinson’s Disease (PD) is the 2nd most frequent neurodegenerative disease worldwide. Upon disease clinical diagnosis already 80% of brain dopaminergic neurons has died. Deep Brain Stimulation (DBS) significantly ameliorates the disease motor symptoms. RNA-Seq analysis of patient’s and controls blood leukocyte RNA revealed significant gene expression and alternative splicing changes in multiple disease relevant genes (including SNCA, PARK7 Il6 TNF-alpha and LRKK2). Small RNA-Seq data analysis released reversible changes in microRNAs (miRNAs). My study may open opportunities for future disease clinical diagnosis through blood test and a better understanding of the disease underlying molecular mechanisms.
Biography
Lilach Soreq has completed his PhD at the age of 36 years from the Hebrew University of Jerusalem, Israel. She studied gene expression changes in PD blood leukocytes prior to and following deep brain stimulation (DBS) and as compared to controls, exon microarray analysis of aging of human brain and single cell RNA-Seq analysis of Alzheimer’s disease. She has 27 scientific publications that have been cited over 1,800 mes, and his publication h-index is 19. She had a 2 year Marie Curie fellowship, 3 years Alzheimer’s Society and 3 years RoseTrees grants. She has been serving as an editorial board member of several reputed journals.
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