Andrea Szkaliczki
University of Pecs, HungaryPresentation Title:
Sleep pattern disturbances and related metabolic alterations as potential biomarkers in neuropsychiatrical functioning
Abstract
Differential diagnostic of mental disorders or mental variations in the population is one of the most debated area because of its complexity. There are often no objective markers that could help to identify "specific" diseases. Most patients have multidiagnos and psychosocial factors should also be considered. Sleep disturbances are a common phenomena in mental disorders. Insomnia, hypersomnia and different circadian rhythm sleep-wake disorders are related most to them. Patients with neurological disorders like epilepsy or Parkinson's disease show mental symptoms as well and have disregulated sleep-wake cycle. Appropriate circadian rhythm regulation of homeostas is essential to achieve healthy hormonal status and metabolism. Disturbances of oxidative stress regulation and of thyroid function, together with altered glucose and lipid metabolism are often seen in the psychiatric population. Severity of sleep-wake rythm variations go hand in hand not just with cognitive - affective symptoms but with those hormonal and metabolic imbalances as well. Understanding the bidirectional connection between metabolic regulation and neuropsychological functions is the key of future scientific perspectives.Identification of specific brain network alterations and to determine potential cognitive-metabolic markers to them would be crucial in order to learn more about neuropsychiatrical functioning and in order to find adequate therapeutic strategies in certain diseases. The objective of the lecture is to summarize recent knowledge about the role of sleep-wake cycle disturbances and related metabolic–neurochemical alterations, that could highlight the potential role of them as biomarkers or predictive factors of neuropsychiatrical functioning.
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